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Medchemexpress LLC Not found on product page (SDS link not accessible) | 2607138-82-7 | MFCD34602688; MFCD33402167 | 99.9% | 461.79 | C19H16ClF4N3O4 | 5 MG
Supplier: Medchemexpress LLC HY1392895MG
ART812 is a small-molecule, orally active inhibitor of DNA polymerase theta (Polθ) with high biochemical potency (Polθ IC50 ~7.6 nM). It exhibits cellular activity in microhomology-mediated end joining (MMEJ) assays (IC50 ~240 nM) and has been investigated preclinically for targeting homologous recombination-deficient tumors and for overcoming PARP inhibitor resistance.
- High biochemical potency: Polθ IC50 ~7.6 nM
- Cellular activity in MMEJ assays (IC50 ~240 nM)
- Orally active small molecule suitable for in vivo studies
- Mechanism targets Polθ-mediated DNA repair pathways
- Investigated for synthetic-lethal targeting of HR-deficient tumors
- High reported purity (~99.9%) for research use
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