Apexbio Technology LLC Novobiocin Sodium 1476-53-5 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B19925.1

Novobiocin Sodium (1476-53-5) is a small-molecule inhibitor targeting bacterial DNA gyrase and heat shock protein 90 (Hsp90) It is designed to inhibit DNA gyrase disrupting bacterial DNA replication and to antagonize Hsp90 by impairing its ATP-binding domain thereby affecting protein maturation Novobiocin Sodium exerts its biological activity primarily through inhibition of the ATPase activity of DNA gyrase and antagonism of Hsp90 Novobiocin-mediated inhibition exhibits reported IC50 values ranging from approximately 0 2 M to 10 M depending on assay conditions and targeted protein context Based on these pharmacological properties Novobiocin Sodium holds research potential in investigating bacterial resistance mechanisms involving pathogens such as Streptococcus pneumoniae and in studies evaluating anti-orthopoxvirus mechanisms

Catalog No. 50-000-92992