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Sigma Aldrich Fine Chemicals Biosciences NOX Inhibitor IV GKT136901

Supplier:  Sigma Aldrich Fine Chemicals Biosciences 5340320001

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An orally bioavailable non-toxic pyrazolopyridinedione based compound that acts as a potent and reversible inhibitor of NOX1- and NOX4-containing NADPH oxidase activity (Ki 160 and 165 nM respectively Amplex Red assay) and devoid of antioxidant properties. At higher concentrations affects NOX2 (Ki 1.53 uM). Blocks NOX-mediated ROS (reactive oxygen species) outburst in NOX isozyme expressing PMN cell membranes. Exhibits poor affinity towards xanthine oxidase lipoxygenases-5/12 myeloperoxidase MAO-B iNOS and eNOS several cytochrome P450 isozymes PTP1B and a panel containing representative ion-channels and kinases at 10 181M. functions as a selective scavenger of peroxynitrite over nitric oxide superoxide radical anion and hydroxyl radical.Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided re

Catalog No. 50-289-8320


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