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Apexbio Technology LLC NP118809 41332-24-5 200mg
SDP

Supplier:  Apexbio Technology LLC A3666200

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NP118809 (CAS 41332-24-5) is a potent and selective blocker of N-type voltage-gated calcium channels exhibiting an IC50 of 0 11 M in vitro It demonstrates significant selectivity over L-type calcium channels with over 100-fold preference (L-type IC50 12 2 M) In vivo studies in rats indicate that NP118809 is orally bioavailable (mean 30%) with a Tmax of 2 3 hours and a half-life of 2 1 hours following intravenous or oral administration The compound exhibits wide tissue distribution and has been shown to produce analgesic effects in animal pain models NP118809 is useful for research into N-type calcium channel function and modulation particularly in studies of pain signaling and neuropharmacology

Catalog No. 50-000-93750


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