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Cayman Chemical npIcastathydrochlorIde 10mg
Supplier: Cayman Chemical 2212610 MG
An inhibitor of DBH (IC50 = 9 nM for the purified human enzyme); selective for DBH over a panel of 12 enzymes and 13 neurotransmitter receptors (IC50s or Kis = >10 μM); dose-dependently reduces norepinephrine content and increases dopamine content in the mesenteric artery, left ventricle, and cerebral cortex in spontaneously hypertensive rats, as well as in the renal artery, left ventricle, and cerebral cortex in beagle dogs; attenuates increases in diastolic blood pressure and heart rate induced by preganglionic sympathetic nerve stimulation in pithed spontaneously hypertensive rats at 10 and 30 mg/kg; reduces the progressive ratio response for cocaine, but not food or sucrose pellets, in rats at 50 mg/kg; reduces reinstatement of cocaine-seeking behavior induced by cues, yohimbine, or foot-shock in rats
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