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Apexbio Technology LLC NPPB 107254-86-4 50mg
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Catalog No. 502240208
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NPPB (5-nitro-2-(3-phenylpropylamino)-benzoic acid CAS 107254-86-4) is a small molecule inhibitor of chloride ion channels It acts via interaction sites that include a negatively charged carboxyl group a secondary amine and a nitro substituent contributing partial negative charge facilitating polar interactions with aromatic residues NPPB inhibits chloride currents with reported IC50 values of 80 nM for short-circuit current assays In rat portal vein cells NPPB reduces calcium-activated chloride currents by 58 96% and suppresses up to 90% of norepinephrine- and acetylcholine-induced BK(Ca) potassium currents It also inhibits volume-activated taurine influx (IC50 12 M) NPPB is utilized in studies dissecting chloride and potassium channel function and volume-regulated organic solute transport

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Catalog No. 50-224-0208 Supplier Apexbio Technology LLC Supplier No. B636750
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NPPB (5-nitro-2-(3-phenylpropylamino)-benzoic acid CAS 107254-86-4) is a small molecule inhibitor of chloride ion channels It acts via interaction sites that include a negatively charged carboxyl group a secondary amine and a nitro substituent contributing partial negative charge facilitating polar interactions with aromatic residues NPPB inhibits chloride currents with reported IC50 values of 80 nM for short-circuit current assays In rat portal vein cells NPPB reduces calcium-activated chloride currents by 58 96% and suppresses up to 90% of norepinephrine- and acetylcholine-induced BK(Ca) potassium currents It also inhibits volume-activated taurine influx (IC50 12 M) NPPB is utilized in studies dissecting chloride and potassium channel function and volume-regulated organic solute transport

This item is not returnable. View return policy
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