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Cayman Chemical nrIdronIc AcId 10mg
Supplier: Cayman Chemical 2969210 MG
An amino bisphosphonate that inhibits FPP synthase (IC50 = 388.2 nM in a cell-free assay); reduces the number of RAW 264.7 cells expressing TRAP in an in vitro model of osteoclastogenesis induced by co-culture with CRL-12257 osteoblasts from 0.001-100 µM; inhibits FGF2-induced proliferation and tube formation in HUVECs at 30 µM; reduces the loss of trabeculae and increases bone density in the tibial metaphysis of growing rats at 0.1 mg/kg per day s.c.
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