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Cayman Chemical nrvonIc AcId methyl ester 50mg

Supplier: Cayman Chemical 900135150 MG

A TRPA1 inhibitor (IC50s 16 and 63 nM for the human and rat receptor respectively) selective for TRPA1 over a variety of receptors ion channels transporters and enzymes at 10 UM but weakly inhibits ERa PR-B and DAT (IC50s 5000 5000 and 1200 nM respectively) reduces the number of flinches and the duration of paw licking in a rat model of cinnamaldehyde-induced nocifensive behavior at 3 10 and 30 mg/kg reduces CFA-induced inflammatory pain in rats at 3-10 mg/kg reverses mechanical allodynia in a rat model of spinal nerve ligation-induced neuropathic pain at 90 mg/kg twice per day
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