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AdipoGen anti-NS5B (HCV), mAb (5B-3B1) (100 µg)
SDP

Supplier:  AdipoGen AG20B0002C100

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Monoclonal Antibody. Recognizes HCV NS5B (epitope mapped to NS5B aa 372-382). It recognizes genotype 1 a and also 1b (albeit with lower affinity). It does not recognize genotype 2a. Isotype: Mouse IgG2b. Clone: 5B-3B1. Applications: WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.

Catalog No. 50-205-2899


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