Medchemexpress LLC NS8593 hydrochloride | 875755-24-1 | 99.76% | 299.80 | 1 MG

Supplier:  Medchemexpress LLC HY11010510MM/1ML

NS8593 hydrochloride is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels). It reversibly inhibits SK3-mediated currents with a Kd value of 77 nM. NS8593 hydrochloride inhibits all SK1-3 subtypes in a Ca2+-dependent manner (Kds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+), but does not affect intermediate and large conductance Ca2+-activated K+ channels (hIK and hBK channels, respectively). It is for research use only and not sold to patients.

• Potent and selective small conductance Ca2+-activated K+ channels inhibitor
• Reversibly inhibits SK3-mediated currents with a Kd value of 77 nM
• Inhibits SK1-3 subtypes Ca2+-dependently
• Does not affect intermediate and large conductance Ca2+-activated K+ channels
• Affects firing rate and firing pattern of dopaminergic neurons in vivo in C57Bl/6 mice at doses of 3 and 10 mg/kg intravenously

Catalog No. 50-003-44968