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Medchemexpress LLC NS8593 (hydrochloride) | 875755-24-1 | 99.8% | 299.80 | 25 MG
Supplier: Medchemexpress LLC 25MGHY110105
NS8593 hydrochloride is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels). It reversibly inhibits SK3-mediated currents with a Kd value of 77 nM. It also inhibits SK1-3 subtypes in a Ca2+-dependent manner (Kds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+), but it does not affect intermediate and large conductance Ca2+-activated K+ channels (hIK and hBK channels).
- Potent and selective small conductance Ca2+-activated K+ channels (SK channels) inhibitor.
- Reversibly inhibits SK3-mediated currents.
- Active on apamin-insensitive SK3 channels.
- Affects firing rate and pattern of dopaminergic neurons in vivo.
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