Apexbio Technology LLC NSC 687852 (b-AP15) 1009817-63-3 200mg

Supplier:  Apexbio Technology LLC A4453200

NSC 687852 (b-AP15 CAS 1009817-63-3) is a small-molecule inhibitor that targets the 19S regulatory particle of the proteasome specifically inhibiting the deubiquitinating enzymes USP14 and UCHL5 without affecting core proteasome activity By blocking these enzymes NSC 687852 disrupts ubiquitin-dependent protein degradation resulting in accumulation of polyubiquitinated proteins induction of caspase-dependent apoptosis cell cycle arrest and activation of the unfolded protein response in multiple myeloma (MM) cell lines and patient-derived cells including those resistant to bortezomib In vivo NSC 687852 has demonstrated good tolerability tumor growth inhibition and lifespan extension in MM xenograft models and exhibits synergistic antitumor effects in combination regimens

Catalog No. 50-000-94993