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Apexbio Technology LLC NSC23766 trihydrochloride 1177865-17-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A19525.1
NSC23766 trihydrochloride (CAS 1177865-17-6) is a selective inhibitor of the Rac1 GTPase It functions by binding specifically to guanine nucleotide exchange factors (GEFs) such as Trio and Tiam preventing their interaction with Rac1 and thus inhibiting Rac1 activation NSC23766 demonstrates an IC50 of approximately 50 M It has been used in various cellular models to study Rac1-dependent processes including endothelial barrier integrity and apoptosis regulation By modulating Rac1 activity NSC23766 serves as a tool compound for investigating the role of Rac signaling pathways in cellular apoptosis especially TNF- -induced JNK activation and barrier function dynamics
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