Medchemexpress LLC NSC319726 (ZMC1) | 71555-25-4 | 99.6% | 234.32 | 100 MG

Supplier:  Medchemexpress LLC HY18634100MG

NSC319726 (ZMC1) is a mutant p53R175 reactivator. It inhibits the growth of fibroblasts expressing the p53R175 mutation with an IC50 of 8 nM, showing no inhibition for p53 wild-type cells. This compound has demonstrated significant inhibition of tumor growth in TOV112D (p53R175H) xenografts in vivo, providing evidence for allele-specific p53 mutant reactivation.

• Mutant p53R175 reactivator with IC50 of 8 nM against p53R175 mutation
• No inhibition for p53 wild-type cells
• High sensitivity for MEF-p53R172H/R172H cell line
• Inhibits tumor growth in TOV112D (p53R175H) xenografts in vivo
• Provides in vivo evidence for allele-specific p53 mutant reactivation
• CC50 < 0.02 μM for Caco-2 cell toxicity
• IC50 < 0.02 μM for Caco-2 cell SARS-CoV-2 cytotoxicity inhibition
• EC50 0.005 μM for TOV112D cell growth inhibition

Catalog No. 50-003-87865