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Medchemexpress LLC NSC697923 | 343351-67-7 | 99.9% | 267.26 | 100 MG

Supplier: Medchemexpress LLC HY13811100MG
NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. It induces neuroblastoma (NB) cell death by promoting the nuclear importation of p53 in p53 wild-type NB cells and by activating the JNK-mediated apoptotic pathway in p53 mutant NB cells. It also inhibits DNA damage and NF-κB signaling, demonstrating antitumor activity.
- Induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells.
- Induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway.
- Inhibits DNA damage and NF-κB signaling.
- Demonstrates antitumor activity.
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