Cayman Chemical nsna wbbauna Notoptl 10mg

Supplier:  Cayman Chemical 3926810 MG

A furanocoumarin with diverse biological activities; a JAK2 and JAK3 inhibitor (IC50s = 9.51 and 25.2 µM, respectively); selective for JAK2 and JAK3 over TYK2 and JAK1 (IC50s = >667 and >2,000 µM, respectively); induces apoptosis and mitochondrial membrane depolarization in HL-60 cells at 40 and 60 µM; induces cell cycle arrest at the G0/G1 phase in HL-60 cells at 10, 20, and 40 µM; decreases acetic acid-induced writhing and vascular permeability in mice at 100 mg/kg; increases the duration of pentobarbital-induced sleep in mice at 10 or 30 mg/kg; reduces joint swelling, inhibits decreased talus bone volume, and reduces meniscus and talus osteoclast numbers in a mouse model of collagen-induced arthritis at 20 mg/kg per day

Catalog No. 50-291-9104