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Genscript Corporation NT-4 Mouse
Supplier: Genscript Corporation Z0318050
Neurotrophin-4 (NT-4) also known as NT-5 is a neurotrophic factor structurally related to -NGF BDNF and NT-3 Human NT-4 shares 48 - 52% aa sequence identity with human -NGF BDNF and NT-3 Neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds NT-4 is expressed highest levels in prostate lower levels in thymus placenta and skeletal muscle NT-4 binds and induces receptor dimerization and activation of TrkB NT-4 can signal through TrkB receptors and promotes the survival of peripheral sensory sympathetic neurons
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