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Invitrogen™ Human NTRK1 (TRKA), His Tag Recombinant Protein

Catalog No. PV3144
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PV3144 10 μg
PR4672D 100 μg
PV4114 1 mg
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Catalog No. PV3144 Supplier Invitrogen™ Supplier No. PV3144
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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Cytoplasmic.

NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
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Specifications

Accession Number P04629
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50mM tris with 0.2mM EDTA, 100mM NaCl, 5mM DTT, 50% glycerol, 0.05% Triton X-100 and no preservative; pH 7.5
Gene ID (Entrez) 4914
Molecular Weight (g/mol) 42.8 kDa
Name Human NTRK1 (TRKA), His Tag
pH Range 7.5
Purification Method Purified
Quantity 10 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias C80751; DKFZp781I14186; EC 2.7.10.1; gp140trk; high affinity nerve growth factor receptor; kinase TrkA; MTC; neurotrophic receptor tyrosine kinase 1; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Ntrk1; Oncogene TRK; p140-TrkA; Slow nerve growth factor receptor; Tkr; TRK; TRK1; TRK1-transforming tyrosine kinase protein; Trka; Trk-A; TrkA neurotrophin receptor; trkA proto-oncogene receptor; tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A
Common Name TrkA
Gene Symbol Ntrk1
KinaseFamily Neurotrophic Receptor (NTRK) Kinase Family
Protein Length 441-796
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-tag
Sequence 441-796
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Assay Entry Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity
Kinase Group Tyrosine Kinases
Shipping Condition Dry Ice
System Compatibility LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™, Omnia™ Bulk Substrate
Target Entry NTRK1
Target Gene neurotrophic tyrosine kinase, receptor, type 1
Expression System Insect cells
Protein Family Kinases & Inhibitors
Protein Form Recombinant, Cytoplasmic
Form Liquid
Protein Subtype Receptor Tyrosine Kinases
Research Category Signal Transduction
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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