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Apexbio Technology LLC Nu 6027 220036-08-8 10mg
Supplier: Apexbio Technology LLC A198610
Nu 6027 (CAS 220036-08-8) is a small-molecule inhibitor originally developed as a CDK2 inhibitor later identified as a selective inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase exhibiting an IC50 of 6 7 M in cell-based assays ATR is involved in the cellular response to DNA replication stress and DNA damage regulating checkpoint activation and DNA repair pathways Nu 6027 enhances the cytotoxicity of agents such as hydroxyurea and cisplatin in an ATR-dependent manner attenuates G2/M cell cycle arrest following DNA damage and inhibits RAD51 foci formation The compound has also demonstrated synthetic lethality in conjunction with defects in single-strand break repair Nu 6027 is utilized in preclinical studies investigating the modulation of DNA damage response pathways in cancer research
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