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Apexbio Technology LLC NU7441 (KU-57788) 503468-95-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A83155.1
NU7441 (KU-57788 CAS 503468-95-9) is a selective inhibitor targeting DNA-dependent protein kinase (DNA-PK) via competition with ATP exhibiting an IC50 of approximately 13 nM and a Ki of 0 65 nM It demonstrates high specificity showing minimal inhibition of related kinases ATM and ATR at concentrations up to 100 M and substantially weaker activity towards mTOR and PI3K (IC50 values of 1 7 and 5 M respectively) NU7441 sensitizes HeLa cells to etoposide enhancing cytotoxicity and augments tumor growth delay when co-administered in SW620 xenograft mouse models The molecule serves as a tool compound in DNA repair and oncology research
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