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STEMCELL Technologies NU7441, Size: 5 mg
Supplier: STEMCELL Technologies 74082
NU7441 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway. It is highly selective for DNA-PK, with an IC₅₀ of 14 nM (Leahy et al.). GENOME EDITING·Reduces the frequency of NHEJ and increases the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Robert et al.).CANCER RESEARCH· Sensitizes human cancer cell lines to DNA double-strand-break-inducing therapies (chemo- or radio-therapy) by inhibiting DNA-PK activity and delaying the repair of double-strand breaks (Ciszewski et al.; Shaheen et al.; Yang et al.; Zhao et al.).
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