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Cayman Chemical Nuclear Factr of ActIvated T

Supplier: Cayman Chemical 34038384 WELL

A PD-1/PD-L1 interaction inhibitor (IC50 12.5 nM in an HTRF assay) increases IFN-Y production by isolated human PMBCs in co-culture with anti-CD3 single-chain variable fragment- and PD-L1-expressing Hep3B hepatoma cells (EC50 ~3 UM) reduces tumor growth in a B16/F10 murine melanoma model and an H22 murine hepatocellular carcinoma model at 25 50 and 100 mg/kg
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