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Cayman Chemical nurofIbrIlary Tngle BODIPY
Supplier: Cayman Chemical 40243100 UG
A fluorescent probe for neurofibrillary tangles; binds to tau-K18 aggregates in a cell-free assay (Kd = 16.8 nM) and is 2.17-fold selective for tau-K18 over Aβ42 aggregates; has been used to label NFTs in postmortem hippocampus from patients with Alzheimer’s disease; has been used to identify tauopathy in vivo and ex vivo in transgenic human tauP301L-expressing mice with a lower signal occurring in the brain of wild-type mice; ex/em = 570-600/710-774 nm in methylene chloride, THF, methanol, DMSO, and PBS
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