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Medchemexpress LLC Nusinersen | 1258984-36-9 | 7127.30 | 10 MG
Supplier: Medchemexpress LLC HY11298010MG
Nusinersen is an antisense oligonucleotide active molecule that functions by modifying the pre-messenger RNA splicing of the SMN2 gene, promoting the production of full-length SMN protein. It has been shown to improve spinal muscular atrophy, ameliorating motor function and preventing motoneuron Cajal body disassembly in SMA mouse models.
- Functions as an antisense oligonucleotide active molecule
- Modifies pre-messenger RNA splicing of the SMN2 gene
- Promotes production of full-length SMN protein
- Improves spinal muscular atrophy
- Ameliorates motor function in SMA mouse models
- Prevents motoneuron Cajal body disassembly
- Rescues skeletal muscle fiber size and oxidative metabolism
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