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Apexbio Technology LLC Nutlin-3a chiral 675576-98-4 200mg
Supplier: Apexbio Technology LLC A3671200
Nutlin-3a chiral (CAS 675576-98-4) is a small-molecule antagonist targeting mouse double minute 2 (MDM2) which functions as a negative regulator of the tumor suppressor TP53 By binding directly to the TP53-interacting pocket of MDM2 Nutlin-3a blocks the degradation of TP53 stabilizing the protein and activating TP53-dependent pathways Studies in solid tumors and lymphomas indicate that Nutlin-3a induces cell cycle arrest growth inhibition and apoptosis Research has demonstrated antitumor activity in vitro and in vivo highlighting its utility in studying TP53-related cell signaling pathways and its potential in cancer research applications
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