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Apexbio Technology LLC Nutlin-3b 675576-97-3 5mg
Supplier: Apexbio Technology LLC A20055
Nutlin-3b (CAS 675576-97-3) is the inactive enantiomer of the small molecule Nutlin-3 a known MDM2 inhibitor Unlike its active counterpart Nutlin-3a Nutlin-3b exhibits minimal affinity for MDM2 approximately 200-fold lower and lacks the capacity to stabilize wild-type TP53 or influence cell cycle progression proliferation or gene expression associated with TP53 signaling Nutlin-3b does not induce MDM2 p53 or p21 expression nor does it affect colony formation in cancer cell lines such as H460 Due to its negligible biological activity Nutlin-3b serves as a negative control in studies investigating p53 MDM2 interactions and the specific effects of active MDM2 antagonists in cellular and molecular oncology research
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