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Medchemexpress LLC NVP 231 | 362003-83-6 | 99.7% | 431.55 | 500 MG
Supplier: Medchemexpress LLC HY13945500MG
NVP 231 is a potent, specific, and reversible ceramide kinase (CerK) inhibitor with an IC50 of 12 nM, which competitively inhibits the binding of ceramide to CerK. It induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage.
- Potent, specific, and reversible CerK inhibitor.
- IC50 of 12 nM for CerK.
- Competitively inhibits ceramide binding to CerK.
- Induces cell apoptosis.
- Reduces cellular CerK activity (IC50: 59.70 ± 12 nM).
- Decreases cell viability dose-dependently.
- Induces caspase-3 and caspase-9 cleavage and activation.
- Upregulates cyclin B1 phosphorylation at Ser133.
- Reduces CDK1 phosphorylation at Tyr15.
- Total CDK1 expression declined.
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