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Medchemexpress LLC NVP-AST 487 | 630124-46-8 | 98.9% | 529.56 | 100 MG
Supplier: Medchemexpress LLC HY15002100MG
AST 487 (NVP-AST 487) is a potent RET kinase inhibitor and also inhibits Flt-3, KDR, c-Kit, and c-Abl kinases. It demonstrates strong inhibitory effects on the growth of human thyroid cancer cell lines with activating RET mutations and mutant FLT3 inhibitor activity, making it suitable for various research applications in cancer and other related disease areas.
- Inhibits RET kinase with an IC50 of 880 nM
- Inhibits Flt-3 with an IC50 of 520 nM
- Potently inhibits growth of human thyroid cancer cell lines with activating RET mutations
- Novel, mutant FLT3 inhibitor
- Inhibits KDR, c-Kit, and c-Abl kinase
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