Apexbio Technology LLC NVP-BGJ398 phosphate 1310746-10-1 100mg

Supplier:  Apexbio Technology LLC A3673100

NVP-BGJ398 phosphate (CAS 1310746-10-1) is a potent selective inhibitor of fibroblast growth factor receptors (FGFRs) 1 2 and 3 exhibiting low nanomolar inhibitory activity (IC50 0 9 nM for FGFR1 1 nM for FGFR3 and 1 4 nM for FGFR2) It demonstrates markedly reduced potency against FGFR4 In cellular assays NVP-BGJ398 suppresses autophosphorylation of FGFRs leading to inhibition of downstream signaling pathways such as ERK1/2 The compound effectively reduces proliferation in cancer cell lines harboring FGFR genetic alterations and promotes cell-cycle arrest and apoptosis in cells with FGFR2 mutations NVP-BGJ398 is under investigation in oncology research including phase I clinical trials

Catalog No. 50-000-97110