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Apexbio Technology LLC NVP-BHG712 940310-85-0 200mg
Supplier: Apexbio Technology LLC A8683200
NVP-BHG712 (CAS 940310-85-0) is a selective small molecule inhibitor targeting the EphB4 receptor tyrosine kinase exhibiting an ED50 of 5 nM for EphB4 and reduced activity toward VEGFR2 (ED50 4200 nM) NVP-BHG712 demonstrates potent inhibition of EphB4 phosphorylation in cellular assays and shows weaker effects on EphB2 EphA2 EphB3 and EphA3 In cell-based models NVP-BHG712 suppresses proliferation and viability of synovial sarcoma cells and increases paclitaxel sensitivity in HEK293/ABCC10 cells In vivo it inhibits VEGF-induced angiogenesis and reduces tumor growth and metastasis in murine xenograft models This compound is a valuable probe for studying EphB4-mediated signaling in cancer and angiogenesis research
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