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Medchemexpress LLC NVP-BSK805 dihydrochloride | 1942919-79-0 | 99.0% | 563.47 | 100 MG
SDP

Catalog No. 5000361972
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NVP-BSK805 dihydrochloride is an ATP-competitive JAK2 inhibitor with IC50s of 0.48 nM for JAK2 JH1, 31.63 nM for JAK1 JH1, 18.68 nM for JAK3 JH1, and 10.76 nM for TYK2 JH1. It inhibits both wild-type and V617F mutant JAK2 activity. This compound suppresses the growth of JAK2V617F-bearing acute myeloid leukemia cell lines and blocks STAT5 phosphorylation. In vivo, it blocks STAT5 phosphorylation, splenomegaly, and leukemic cell spreading, and suppresses rhEpo-mediated polycythemia.

  • ATP-competitive JAK2 inhibitor
  • Inhibits wild-type and V617F mutant JAK2 activity
  • Suppresses growth of acute myeloid leukemia cell lines
  • Blocks STAT5 phosphorylation
  • Enhances P-gp inhibitory activity
  • Sensitizes drug-resistant cancer cells
  • Blocks splenomegaly and leukemic cell spreading
  • Suppresses rhEpo-mediated polycythemia

Catalog No. 50-003-61972 Supplier Medchemexpress LLC Supplier No. HY14722A100MG
May include imposed supplier surcharges.
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NVP-BSK805 dihydrochloride is an ATP-competitive JAK2 inhibitor with IC50s of 0.48 nM for JAK2 JH1, 31.63 nM for JAK1 JH1, 18.68 nM for JAK3 JH1, and 10.76 nM for TYK2 JH1. It inhibits both wild-type and V617F mutant JAK2 activity. This compound suppresses the growth of JAK2V617F-bearing acute myeloid leukemia cell lines and blocks STAT5 phosphorylation. In vivo, it blocks STAT5 phosphorylation, splenomegaly, and leukemic cell spreading, and suppresses rhEpo-mediated polycythemia.

  • ATP-competitive JAK2 inhibitor
  • Inhibits wild-type and V617F mutant JAK2 activity
  • Suppresses growth of acute myeloid leukemia cell lines
  • Blocks STAT5 phosphorylation
  • Enhances P-gp inhibitory activity
  • Sensitizes drug-resistant cancer cells
  • Blocks splenomegaly and leukemic cell spreading
  • Suppresses rhEpo-mediated polycythemia

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