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Medchemexpress LLC NVP-BSK805 dihydrochloride | 1942919-79-0 | 99.0% | 563.47 | 25 MG
Supplier: Medchemexpress LLC 25MGHY14722A
NVP-BSK805 dihydrochloride is an ATP-competitive inhibitor primarily targeting JAK2, with high selectivity over other JAK family members like JAK1, JAK3, and TYK2. It effectively suppresses the growth of JAK2V617F-bearing acute myeloid leukemia cell lines and blocks STAT5 phosphorylation. This compound also enhances the sensitivity of drug-resistant cancer cells to certain treatments by improving P-gp inhibitory activity.
- Potent ATP-competitive JAK2 inhibitor
- Selective inhibition over JAK1, JAK3, and TYK2
- Suppresses JAK2V617F-bearing acute myeloid leukemia cell growth
- Blocks STAT5 phosphorylation
- Improves P-gp inhibitory activity
- Increases sensitization of drug-resistant cancer cells to treatments
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