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Apexbio Technology LLC NVP DPP 728 dihydrochloride 247016-69-9 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A44275.1

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NVP DPP 728 dihydrochloride (CAS 247016-69-9) is a potent orally active inhibitor of dipeptidyl peptidase IV (DPP-IV) Mechanistically it reversibly inhibits human DPP-IV enzyme through formation of a nitrile-dependent complex characterized by transitional-state kinetic properties exhibiting a Ki of 11 nM In aged rat models oral administration of NVP DPP 728 reduces plasma DPP-IV activity enhances early-phase insulin secretion and improves glucose tolerance following glucose challenge This compound is under preclinical investigation for type 2 diabetes research targeting the DPP-IV/glucagon-like peptide-1 pathway

Catalog No. 50-000-62263


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