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Medchemexpress LLC NX-2127 | 2416131-46-7 | C39H45N9O5 | 200 MG
Supplier: Medchemexpress LLC HY153220200MG
Zelebrudomide (NX-2127) is an orally active PROTAC degrader targeting Bruton's Tyrosine Kinase (Btk). It effectively inhibits proliferation of BTKC481S mutant TMD8 cells and catalyzes degradation of Ikaros (IKZF1) and Aiolos (IKZF3). It also stimulates T cell activation and increases IL-2 production.
- Orally active PROTAC degrader.
- Targets Bruton's tyrosine kinase (Btk).
- Inhibits BTKC481S mutant TMD8 cell proliferation (EC50 <30 nM).
- Catalyzes Ikaros (IKZF1) and Aiolos (IKZF3) degradation.
- Stimulates T cell activation; increases IL-2 production.
- Potent BTK degradation in cynomolgus monkeys in vivo.
- Superior tumor growth inhibition in WT TMD8 and C481S mutant xenograft models.
- Appearance: solid, light yellow to yellow.
- Purity: 99.72%.
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