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Selleck Chemical LLC o-Phenanthroline
Supplier: Selleck Chemical LLC S6830100MG
o-Phenanthroline (1 10-Phenanthroline phen) a hypoxia-mimicking agent is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110 5 M for Collagenase O-phenanthroline reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs) as well as after TNF /IL-1 exposure in an explant model o-Phenanthroline is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2 that absorbs maximally at 510 nm
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