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Apexbio Technology LLC o-Phenanthroline 66-71-7 10g
Supplier: Apexbio Technology LLC B785410000
o-Phenanthroline (CAS 66-71-7) is a cell-permeable metal chelator that functions as a non-selective inhibitor of matrix metalloproteinases (MMPs) which are zinc-dependent enzymes implicated in extracellular and intracellular matrix remodeling under stress conditions It has been shown to suppress MMP-2-mediated proteolysis of nuclear lamins in vitro indicating a direct effect on structural nuclear proteins In myocardial ischemia-reperfusion models o-Phenanthroline treatment improved cardiac function parameters such as left ventricular developed pressure and coronary flow during reperfusion This compound is widely used in studies investigating MMP activity oxidative stress injury and tissue remodeling
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