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Apexbio Technology LLC O6-Benzylguanine 19916-73-5 250mg
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Catalog No. 5000063604
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O6-Benzylguanine (CAS 19916-73-5) is a small molecule inhibitor of O6-methylguanine DNA methyltransferase (MGMT) a DNA repair enzyme responsible for removing alkyl groups from the O6 position of guanine residues restoring DNA integrity By irreversibly inactivating MGMT O6-Benzylguanine reduces enzyme stability enhances proteolytic susceptibility and potentiates alkylating agent-induced DNA damage In cancer cell lines (e g HT29 SF767 HCT116) O6-Benzylguanine sensitizes cells to alkylating chemotherapy agents by suppressing MGMT activity and causing prolonged G2/M arrest It is useful in preclinical cancer research investigating chemotherapeutic resistance mechanisms

Catalog No. 50-000-63604 Supplier Apexbio Technology LLC Supplier No. B5974250
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O6-Benzylguanine (CAS 19916-73-5) is a small molecule inhibitor of O6-methylguanine DNA methyltransferase (MGMT) a DNA repair enzyme responsible for removing alkyl groups from the O6 position of guanine residues restoring DNA integrity By irreversibly inactivating MGMT O6-Benzylguanine reduces enzyme stability enhances proteolytic susceptibility and potentiates alkylating agent-induced DNA damage In cancer cell lines (e g HT29 SF767 HCT116) O6-Benzylguanine sensitizes cells to alkylating chemotherapy agents by suppressing MGMT activity and causing prolonged G2/M arrest It is useful in preclinical cancer research investigating chemotherapeutic resistance mechanisms

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