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Apexbio Technology LLC O6-Benzylguanine 19916-73-5 250mg
Supplier: Apexbio Technology LLC B5974250
O6-Benzylguanine (CAS 19916-73-5) is a small molecule inhibitor of O6-methylguanine DNA methyltransferase (MGMT) a DNA repair enzyme responsible for removing alkyl groups from the O6 position of guanine residues restoring DNA integrity By irreversibly inactivating MGMT O6-Benzylguanine reduces enzyme stability enhances proteolytic susceptibility and potentiates alkylating agent-induced DNA damage In cancer cell lines (e g HT29 SF767 HCT116) O6-Benzylguanine sensitizes cells to alkylating chemotherapy agents by suppressing MGMT activity and causing prolonged G2/M arrest It is useful in preclinical cancer research investigating chemotherapeutic resistance mechanisms
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