Sigma Aldrich Fine Chemicals Biosciences O9 1 Mouse Cranial Neural

Supplier:  Sigma Aldrich Fine Chemicals Biosciences SCC049

Cranial neural crest cells give rise to ectomesenchymal derivatives such as cranial bones cartilage smooth muscle dentin as well as melanocytes corneal endothelial cells and neurons and glial cells of the peripheral nervous system. Previous studies have suggested that although multipotent stem-like cells may exist during the course of cranial neural crest development they are transient undergoing lineage restriction early in embryonic development. Whole-genome expression profiling of O9-1 cells revealed that this line stably expresses stem cell markers (CD44 Sca-1 and Bmi1) and neural crest markers (AP-2a Twist1 Sox9 Myc Ets1 Dlx1 Dlx2 Crabp1 Epha2 and Itgb1). O9-1 cells are capable of contributing to cranial mesenchymal (osteoblast and smooth muscle) neural crest fates when injected into E13.5 mouse cranial tissue explants and chicken embryos. These results suggest that O9-1 cells represent multipotent mesenchymal cranial neural crest cells. The O9-1 cell line shoul

Catalog No. 50-290-8400