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Medchemexpress LLC OAB-14 | 2140911-49-3 | 99.2% | 518.73 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY13997310MM/1ML

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OAB-14 is a derivative of Bexarotene that improves Alzheimer's disease-related pathologies and cognitive impairments. It works by increasing β-amyloid clearance and ameliorating the dysfunction of the endosomal-autophagic-lysosomal pathway in APP/PS1 transgenic mice. OAB-14 has no significant effect on body weight or liver toxicity after acute and chronic treatment.

  • Improves Alzheimer's disease-related pathologies and cognitive impairments
  • Increases β-amyloid clearance
  • Ameliorates dysfunction of the endosomal-autophagic-lysosomal pathway
  • Promotes microglia phagocytosis
  • Attenuates downstream pathological events of Aβ accumulation
  • Restores autophagy flux via the AMPK/mTOR pathway
  • Enhances lysosomal activity and reduces Aβ accumulation in lysosomes

Catalog No. 50-003-51145


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