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Apexbio Technology LLC Obatoclax mesylate (GX15-070) 803712-79-0 25mg
Supplier: Apexbio Technology LLC A419425
Obatoclax mesylate (GX15-070) is a small-molecule inhibitor targeting multiple anti-apoptotic proteins within the BCL-2 family including BCL-2 BCL-XL MCL-1 A1 and BCL-B It functions by binding to their BH3-binding grooves thereby disrupting interactions with pro-apoptotic proteins such as Bak and Bim promoting apoptotic processes Obatoclax mesylate induces apoptosis in cultured acute myeloid leukemia (AML) cells and primary AML patient samples evidencing inhibitory effects on clonogenic growth with IC50 values below 200 nmol/L In preclinical research applications this compound shows activity in xenograft models of solid tumors and multiple myeloma providing a relevant chemical tool for oncology research focused on apoptotic mechanisms and hematologic malignancies
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