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Medchemexpress LLC Obatoclax mesylate | 803712-79-0 | 99.9% | 413.49 | 1 ML
Supplier: Medchemexpress LLC HY1096910MG
Obatoclax Mesylate is a BH3 mimetic and a pan-BCL-2 family proteins inhibitor that induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. It exhibits anti-cancer and broad-spectrum antiparasitic activity.
- Inhibits BCL-2 family proteins including BCL-2, BCL-XL, MCL-1, BCL-w, A1, and BCL-b
- Induces autophagy-dependent cell death
- Targets cyclin D1 for proteasomal degradation
- Demonstrates anti-cancer and broad-spectrum antiparasitic activity
- Reduces cell numbers in human colorectal cancer cell lines (HCT116, HT-29, LoVo)
- Increases G1-phase cell populations
- Causes a marked drop in cyclin D1 levels, inhibits GSK3β, and activates p38MAPK
- Shows potent antitumor activity in xenograft mouse models
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