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Cayman Chemical Obeldesivir, Purity: ≥98%, CAS: 2647441-36-7, 5 mg
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Catalog No. 502942804
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An antiviral nucleoside analog and a prodrug form of GS-441524; inhibits the replication of SARS-CoV-2 and SARS-CoV-2 Βeta, Gamma, or Omicron variants in infected Vero E6 cells (EC50s = 1.36, 1.127, 0.349, and 0.106 µM, respectively) without inducing cytotoxicity (CC50 = 128 µM); reduces nucleocapsid gRNA copy number and nucleocapsid sgRNA levels in the lungs of, and decreases lung damage in, a KI-hACE2 mouse model of SARS-CoV-2 infection at 250 or 500 mg/kg per day; reduces the levels of S protein in the lungs of, as well as decreases PFUs in lung tissues, reduces lung and spleen inflammation, and prevents viral infection-induced death in, a K18-hACE2 mouse model of SARS-CoV-2 infection at 100 or 250 mg/kg per day

Catalog No. 50-294-2804 Supplier Cayman Chemical Supplier No. 404045 MG
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An antiviral nucleoside analog and a prodrug form of GS-441524; inhibits the replication of SARS-CoV-2 and SARS-CoV-2 Βeta, Gamma, or Omicron variants in infected Vero E6 cells (EC50s = 1.36, 1.127, 0.349, and 0.106 µM, respectively) without inducing cytotoxicity (CC50 = 128 µM); reduces nucleocapsid gRNA copy number and nucleocapsid sgRNA levels in the lungs of, and decreases lung damage in, a KI-hACE2 mouse model of SARS-CoV-2 infection at 250 or 500 mg/kg per day; reduces the levels of S protein in the lungs of, as well as decreases PFUs in lung tissues, reduces lung and spleen inflammation, and prevents viral infection-induced death in, a K18-hACE2 mouse model of SARS-CoV-2 infection at 100 or 250 mg/kg per day

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