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AdipoGen OCH
SDP

Supplier:  AdipoGen AGCR13593M001

Encompass_Preferred

Chemical. CAS 383187-82-4. Formula C39H77NO9. MW 704. Truncated analog of alpha-GalCer. iNKT cell glycolipid agonist. Immunosuppressive. Th2 polarizing. Stimulation of NKT with OCH results in release of primarily Th2 cytokine compared to stimulation with alpha-GalCer, which results in release of a mixture of Th1 and Th2 cytokines. Induces stronger interleukin-4 IL-4 secretion and weaker interferon-gamma IFN-gamma secretion than alpha-GalCer both in vitro and in vivo. Inducer of interleukin-10 IL-10 and suppressor of diabetes. Shown to prevent experimental autoimmune encephalomyelitis EAE in mice, an animal model of multiple sclerosis. Has beneficial effects on type I diabetes in NOD mice. Suppressor of collagen-induced arthritis. Might be useful for immunotherapy of transplant rejection.

Catalog No. 50-256-2270


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