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Cayman Chemical OclacItInIb 50mg
Supplier: Cayman Chemical 1872250 MG
A JAK family kinase inhibitor (IC50s = 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively); selective for JAK kinases over a panel of 38 additional kinases at 1 μM; inhibits LPS-induced increases in IL-12 and TNF-α levels in murine BMDCs in a concentration-dependent manner; topical administration reduces scratching behavior and EAr edema, as well as decreases levels of IL-1β, IL-4, and IL-6 in EAr skin, in a mouse model of TDI-induced allergic dermatitis at 0.1, 0.25, and 0.5%
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