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Diagnostic Biosystems OCT 3/4 OCT-3/4 (OCT4/6847R)
Supplier: Diagnostic Biosystems RMAB113
OCT-3/4 (also known as POU5F1) is a transcription factor that has been recognized as fundamental in the maintenance of pluripotency in embryonic stem cells and primordial germ cells. It has been proposed as a useful marker for germ cell tumors (GCT) that exhibit features of pluripotentiality (seminoma/dysgerminoma, germinoma and embryonal carcinoma. OCT-3/4 immunostaining has been shown to be sensitive and specific for GCT, whether in primary gonadal or extragonadal sites or in metastatic lesions.
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