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Cayman Chemical Octaethylen Glycol mondodec 1g
SDP

Supplier:  Cayman Chemical 209381 G

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CAY10410 is an analog of PGD2/PGJ2 with structural modifications intended to give it PPARY ligand activity and resistance to metabolism 15-deoxy- DELTA 1214-PGJ2 has been shown to be a potent ligand for PPARY 1424 Metabolism of the cyclopentenone prostaglandins PGA2 PGJ2 and DELTA 12-PGJ2 occurs via glutathione addition across the aB unsaturated enone 7193 CAY10410 was designed as an analog of the PPARY-binding prostaglandins which could not undergo this conjugation reaction In human neuroblastoma SH-SY5Y cells CAY10410 was not cytotoxic at up to 25 UM It also failed to covalently modify thioredoxin or induce oxidative stress at 50 UM 12676

Catalog No. 50-298-0814


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