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Apexbio Technology LLC Octyl-α-ketoglutarate 876150-14-0 10mg (solution)
Supplier: Apexbio Technology LLC C432110
Octyl- -ketoglutarate is a membrane-permeable derivative of -ketoglutarate a substrate required for prolyl hydroxylases (PHDs) enzymes regulating the stability of hypoxia-inducible factor-1 (HIF-1 ) through oxygen-dependent hydroxylation Intracellular delivery by octyl conjugation enhances cellular -ketoglutarate availability enabling the restoration of PHD enzymatic function compromised by elevated succinate or fumarate Research indicates its utility in cellular models with impaired TCA-cycle enzymes such as IDH1 mutations facilitating the study of hypoxic signaling pathways and tumor cell pseudohypoxia responses
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