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Medchemexpress LLC ODN 2216 sodium | DNA, d(G-sp-G-sp-G-G-G-A-C-G-A-T-C-G-T-C-G-sp-G-sp-G-sp-G-sp-G-sp-G), sodium salt | 5 MG
Supplier: Medchemexpress LLC HY150741C5MG
ODN 2216 sodium acts as a type A CpG oligodeoxynucleotide vaccine adjuvant and a TLR9 agonist. It interacts with TLR9 in CD4+ T cells, activating pathways to induce type I interferons, IL-6, and TGF-β, and increasing intracellular ATP. It promotes anti-inflammatory T cell differentiation, inhibits proliferation, and enhances CD8+ T cell-mediated cytotoxicity against Mammaglobin-A in breast cancer. Used in breast cancer and systemic lupus erythematosus research.
- Type A CpG oligodeoxynucleotide vaccine adjuvant
- TLR9 agonist
- Modulates immune response via TLR9
- Induces type I interferons, IL-6, and TGF-β
- Increases intracellular ATP levels
- Promotes anti-inflammatory T cell differentiation
- Enhances CD8+ T cell cytotoxicity in breast cancer
- Relevant for breast cancer and lupus erythematosus studies
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