Medchemexpress LLC ODN 2395 | 1254617-22-5 | DNA, d(P-thio)(T-C-G-T-C-G-T-T-T-T-C-G-G-C-G-C-G-C-G-C-C-G) | 1 MG

Supplier:  Medchemexpress LLC HY1507431MG

ODN 2395 is a C class oligodeoxynucleotide and a TLR9 agonist. It can be used as a vaccine adjuvant and in the research of immunological vaccines. Its sequence is 5'-tcgtcgttttcggcgc:gcgccg-3'. The molecular weight is 7035.00. It appears as a white to off-white solid with a purity of 98.20%.

• Used as a vaccine adjuvant.
• Functions as a Toll-like Receptor 9 (TLR9) agonist.
• Applicable in the research of immunological vaccines.
• Increases serum HDL-C and IgG1 levels in normal nutritional status mice infected with *Leishmania donovani*.
• Reduces spleen parasite load and enhances Th1-type immune responses in obese mice infected with *Leishmania donovani*.
• Reduces spleen parasite load and up-regulates key spleen immune activation genes in undernourished mice infected with *Leishmania donovani*.
• Confers 55% survival in HSV-1-infected BALB/c mice with a single intranasal dose prior to infection.

Catalog No. 50-003-75539