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AdipoGen ODN 2006 (Type B) Endotoxin-free (sterile)
Supplier: AdipoGen IAX2000063001
ODN 2006 (Type B) Endotoxin-free (sterile), AdipoGen Life Sciences. Chemical. MW: 7,720g/mol. Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic oligonucleotides (ODN) that contain such CpG motifs (CpG ODNs) mimic microbial DNA. The innate immune system of vertebrates has the ability to recognize CpG motifs in microbial DNA via the Toll-like receptor (TLR) 9 if the CpG ODN were free of additional immune stimulatory contaminants often present in synthetic commercial CpG ODN preparations designed for molecular biology applications (i.e. PCR).
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